| 摘要 |
1-5-Disubstituted-2-pyrrolidones or their intermediates (I; Q = -C(O)OR3, tetrazol-5-yl, -C(O)NHP4; A is single or cis-double bond; B is single or trans-double bond; U = H OH or HO H; R2 = α -thienyl, phenyl, phenoxy; R3 = H, Cl1-5 alkyl, phenyl or p-biphenyl; R4 = -C(O)R5, -SO2R5; R5 = phenyl, C1-5 alkyl) or alkali or alkali earth metal or ammonium salt contg. C5 epimer or carboxylate or tetrazol-5-yl, having a selective and biological activity, were prepd. by reduction of C15-keto group in the intermediate of pyrrolidone (II). Thus, 5 -(tetrahydropyran-2'-yl oxymethyl-2-pyrrolidone 1 was prepd. from 5-D-hydroxymethylene-2-pyrrolidone, methylene chloride, dihydropyran, p-toluene sulfonic acid.
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