| 摘要 |
4(or 3)-(3,4-Dihydroxyphenyl)- pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-(3,4- dimethoxyphenyl) pyridine, preferably by heating with aqueous hydrogen bromide. 4(or 3)-[3,4-di-(OR)-phenyl] pyridine, where R is hydrogen or methyl, or pharmaceutically-acceptable acid- addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-di(OR)-phenyl] pyridine, where R is hydrogen or methyl, is shown for comparative purposes. |
