STILBENE DERIVATIVES

摘要

This invention is concerned with compounds of the general formula (I) wherein n stands for 1 or 2 and, when n stands for 1, R1 and R2 represent hydrogen, lower alkoxy or halogen, or, when n stands for 2, R1 represents hydrogen, lower alkoxy or halogen and R2 represents hydrogen; R3, R4, R5 and R6 represent hydrogen or lower alkyl; R7 represents hydrogen, methyl or ethyl; R8 and R9 represent hydrogen, lower alkyl or halogen; and R10 represents a group of the formula -(CH=CR19)mR11, in which m stands for zero or 1 and R11 represents a group of the formula or or the 2-oxazolinyl group, or, when m stands for 1, also represents hydrogen; R12 represents hydrogen or lower alkyl; R13 represents hydrogen, lower alkyl of a group of the formula -N(R17,R18) or -OR14; R14 represents hydrogen, lower alkyl or alkanoyl; R15 represents hydrogen, lower alkyl or a group of the formula -OR16 or -(CH2)pN(R17, R18) R16 represents hydrogen, lower alkyl, hydroxy-(lower alkyl), aryl, substituted aryl, aralkyl or aralkyl substituted in the aryl portion; R17 and R18 represent hydrogen or lower alkyl or R17 and R18 together with the nitxogen atom to which they are attached represent a heterocyclic group; R19 represents hydroqen or lower alkyl and p stands for zero, 1, 2 or 3; as well as ketals of compounds of formula I in which R11 represents a group of the formula-C(O)R15 and R15 represents hydroqen or lower alkyl, and salts of c????unds of formula I. The invention is also concerned w??? process for the manufacture of these compounds and salts and with pharmaceutical preparations containing them. Tha compounds of formula I and their salts are useful for the treatment of neoplasms, dermatological conditions and rheumatic diseases.