Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo

摘要

The invention provides compositions comprising a carrier comprising a continuous phase of a hydrophobic substance, liposomes, and a polynucleotide, and methods for using such compositions for delivering a polynucleotide to a subject.

主权项

1. An injectable composition comprising:
a carrier comprising mannide oleate and a continuous phase of mineral oil; liposomes comprising an unsaturated phospholipid; and a polynucleotide encapsulated within said liposomes, said polynucleotide encoding a polypeptide and being operably linked to a promoter functional in mammalian cells; wherein said carrier and said liposomes are present in a ratio of 1:1 by volume.