PROCESS FOR THE PREPARATION OF METHYL ESTERS OF ARYLPROPIONIC ACIDS OPTICALLY ACTIVE

摘要

Optically active methyl esters of arylpropionic acids are prepared by reaction of the corresponding vinylaromatic compounds with carbon monoxide and methyl alcohol in the presence of a palladium catalyst system consisting of a palladium compound associated with optically active diphenyl-neomenthyl-phospine and with trifluoroacetic acid, at substantially atmospheric pressure and at a temperature comprised between 20.degree. and 80.degree.C. There is dealt with particular regioselective and enantioselective catalysis conditions. The products obtained consist of esters of arylpropionic acids or of the corresponding acids obtainable from them, and are useful intermediates in the synthesis of organic compounds, particularly of pharmaceutical products.