| 摘要 |
N-(5-Tetrazolyl) pyridine-2-carboxamide and derivs. (I) and their salts are new (where R1 = H, a lower alkyl, a lower alkoxy, halogen, a lower alkylthio or NO2; and R2 = H, a lower alkyl, a lower alkoxy, PhO, Ph-(lower) alkyl, Ph'-(lower) alkenyl or halogen). Cpds. (I) are antiallergic agents with low toxicity (e.g. LD50 of 800 mg/kg orally) and no tolerance or side effects are observed with repeated use. Dose is 0.1 - 300 mg/kg daily. Cpds. (I) in which (a) R1 is H and R2 is Me or styryl, (b) R1 is 4-Cl and R2 is H or Me, and (c) R1 and R2 are Me, are specifically claimed.
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