| 摘要 |
Antibacterially active 11,12-O-methylene derivatives of erythromycin of formula (I) and their pharmaceutically acceptable esters and acid addition salts, wherein: R<1> or R<2> is optionally substituted amino, and R<2> or R<1> is H, or R<1> + R<2> is oxo, optionally substituted oxime or imino; R<3> is H or CH3; R<4> and R<5> are each H or hydrocarbon; R<6> is H, F or OH; R<7> is H or CH3; R<8> or R<9> is H, OH, alkoxy alkanoyloxy, optionally substituted amino, or R<10>-SO2-O-, and R<9> or R<8> is H, or R<8> + R<9> is oxo or optionally substituted oxime; and R<10> is organic. |
