Quinoline-Based Kinase Inhibitors

摘要

The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.;

主权项

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from imidazopyridazine, isoquinolinyl, oxazolyl, pyridinyl, pyrimidinyl, pyrrolopyridinyl, and quinolinyl, wherein each ring is optionally substituted with C1-C3acylamino, C1-C3alkyl, amino, C1-C3alkoxy, C3-C6cycloalkyl, C3-C6cycloalkylamino, C1-C3dialkylamino, —NHCO2(C1-C3)alkyl, and phenylcarbonylamino optionally substituted with a halo or haloalkyl group;R2 is selected from hydrogen, C1-C3alkoxy, and C1-C3alkyl;R3 is selected from hydrogen, C1-C3alkoxy, C1-C3alkyl, cyano, and halo;R4 is selected from C3-C6alkyl optionally substituted with one group selected from amino, haloalkyloxy, hydroxy and oxo; and C3-C6cycloalkylC1-C3alkyl optionally substituted with amino;R5 is selected from hydrogen, C1-C6alkyl, amido, cyano, and halo;when is a double bond, R6 is selected from hydrogen, C1-C6alkoxy, C1-C6alkyl, amido, cyano, C1-C6dialkylamino, halo, hydroxy, and a five-membered heteroaromatic ring; andwhen is a single bond, R6 is =S.