发明名称 Chartreusin analogues
摘要 The present invention relates to novel Chartreusin analogues of formula (I), pharmaceutical compositions comprising the same and to their use for the treatment of cancer and other diseases.
申请公布号 US9522930(B2) 申请公布日期 2016.12.20
申请号 US201314418010 申请日期 2013.07.30
申请人 LEIBNIZ-INSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE 发明人 Hertweck Christian;Dahse Hans-Martin;Ueberschaar Nico;Bretschneider Tom;Scherlach Kirstin;Metsae-Ketelae Mikko
分类号 C07H17/04;C07D493/06;C07H17/08 主分类号 C07H17/04
代理机构 Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. 代理人 Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless, Esq. Peter F.;Clarke Daniel W.
主权项 1. A compound of formula (I) wherein R1 is fucose-digitalose or a 1,4′-bipiperidine-1′carboxylate group; R2 is a hydrogen atom, or a 1,4′-bipiperidine-1′carboxylate group, or a group of formula —X—(CH2—CH2—O)n—R5 wherein X is a bond, a —C(═O)—, —C(═O)—O— or a —C(═O)—Y—O— group wherein Y is an alkylene group, n is an integer of from 2 to 100, and R5 is hydrogen or an alkyl group; R3 is a hydrogen atom, a halogen atom, a hydroxy group, a (C1-C8) alkoxy group, a (C2-C8) alkyl group, a (C2-C8) haloalkyl group, a (C2-C8) alkenyl group, or a (C2-C8) alkynyl group and R4 is hydrogen; or R3 is hydrogen and R4 is a hydrogen atom, a halogen atom, a hydroxy group, a (C1-C8) alkoxy group, a (C2-C8) alkyl group, a (C2-C8) haloalkyl group, a (C2-C8) alkenyl group, or a (C2-C8) alkynyl group; or a pharmaceutically acceptable salt, solvate or hydrate or a pharmaceutically acceptable formulation thereof.
地址 Jena DE