发明名称 |
PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF DIABETES MELLITUS |
摘要 |
Pharmaceutical formulations for the treatment of diabetes mellitus are disclosed, wherein the pharmaceutical formulations contain at least one insulin derivative modified with a base in position B31 of the insulin B chain and having an isoelectric point between 5.8 and 8.5 and/or at least one of its physiologically tolerated salts in a pharmaceutically acceptable excipient and a relatively high zinc ion content in the range from above 1 mu g to about 200 mu g of zinc/IU. The preferred insulin derivative modified with a base for this pharmaceutical formulation is human insulin-B31-Arg-OH and human insulin-B31-Arg-B32-Arg-OH. The formulation is used for the treatment of diabetes mellitus; it has a particularly favorable action profile. |
申请公布号 |
AU3951489(A) |
申请公布日期 |
1990.02.15 |
申请号 |
AU19890039514 |
申请日期 |
1989.08.11 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
MICHAEL DORSCHUG |
分类号 |
A61K38/28;A61P3/08;A61P3/10;C07K14/575;C07K14/62 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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