STABLE AQUEOUS SOLUTIONS OF PRIMYCIN, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THESE SOLUTIONS AND PROCESS FOR PREPARING SAME

摘要

The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin with N-methylpirrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L--pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 600% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount supplementing up to 100%. The invention further relates to pharmaceutical or disinfecting cosmetic compositions mainly for topical treatment containing the above primycin solution optionally in admixture with pharmaceutically acceptable auxiliary materials and, if desired. with other non-synergistic therapeutically active ingredient(s), suitably desquamating and/or antiinflammatory agent(s). The invention further relates to the preparation of the above primycin solutions and compositions containing these solutions.