发明名称 |
A PROCESS FOR THE PREPARATION OF AN INSULIN PRECURSOR IN STREPTOMYCETES |
摘要 |
A gene for a truncated proinsulin in which the insulin B chain is linked to the A chain only via Lys or Lys-Lys is coupled to the tendamistat gene, this gene construct is inserted into an expression vector, and the latter is used to transform a Streptomycetes host cell, with the result that the corresponding fusion protein is expressed and secreted. The fusion protein can easily be cleaved to give insulin precursors. |
申请公布号 |
AU4395089(A) |
申请公布日期 |
1990.05.10 |
申请号 |
AU19890043950 |
申请日期 |
1989.11.01 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
KLAUS-PETER KOLLER;GUNTHER JOHANNES RIESS;EUGEN UHLMANN;HOLGER WALLMEIER |
分类号 |
C12N1/21;C07K14/00;C07K14/36;C07K14/575;C07K14/62;C07K19/00;C12N15/17;C12P21/02;C12R1/465 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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