| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> is (protected) amino; R<2> is lower alkyl, (carboxy-substituted) cycloalkyl or cycloalkyl lower alkyl, etc.; R<3> is formula II-V (n is 1 or 2; m is 0-4; R<6> is lower alkyl, etc.; R<7> is H or cyano lower alkylthio, etc., R<1>2 is lower alkyl) R<13> is H or carbamoyl; B<-> is negative ion;, is 0 or 1); R<4> is carboxylate or carboxy, etc.]. EXAMPLE:Diphenylmethyl (6S,7S)-7-[2-(2-tritylaminothiazol-4-yl)-2- methoxyiminoacetoamide]-3-(1-pyrrolidinyl) methyl- <3>-O-2-isocephem-4- carboxylate (syn-isomer). USE:Antibacterial agent against Gram-positive bacterium or Gram-negative bacterium. PREPARATION:A compound expressed by formula VI (R<9> is halogen, etc.; R<4a> is carboxy, etc.) is reacted with a compound expressed by formula VII. |
