Heterocyclic compound and use thereof

摘要

Provided is a compound having an AMPA receptor function enhancing action, and useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease, attention deficit hyperactivity disorder (ADHD) and the like. The compound represented by formula (I):;
wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has an AMPA receptor function enhancing action, and is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and the like.

主权项

1. A compound represented by the formula (I)wherein
R1 is(1) C1-6 alkyl optionally substituted by 1 to 3 substituents selected from a halogen atom and C1-6 alkoxy;(2) C3-7 cycloalkyl;(3) phenyl optionally substituted by 1 to 3 substituents selected from a halogen atom, cyano, C1-6 alkyl optionally substituted by 1 to 3 halogen atoms and C1-6 alkoxy;(4) dihydrobenzofuranyl;(5) benzodioxolyl substituted by 1 to 3 halogen atoms;(6) pyridyl optionally substituted by 1 to 3 substituents selected from a halogen atom and C1-6 alkyl optionally substituted by 1 to 3 halogen atoms;(7) pyrimidinyl;(8) isoxazolyl substituted by 1 to 3 C1-6 alkyls;(9) tetrahydrofuranyl; or(10) pyrazolyl;
L1 is a bond, —O— or CH2—O—; ring D is a benzene ring; a partial structure:wherein
L2A is a bond or —O—CH2—; or L2B is a bond,or a salt thereof.