Medical Devices Containing Nitroprusside and Antimicrobial Agents

摘要

A medical device includes a structure configured for introduction to a vascular system of a patient. The structure including a surface having sodium nitroprusside and silver disposed thereupon. The sodium nitroprusside has a concentration sufficient to reduce thrombosis. To make the medical device, a base material is impregnated with sodium nitroprusside, the medical device is formed from the base material, and the medical device is coated with an antimicrobial agent.

主权项

1. A vascular catheter comprising:
a polymer base having a bulk distribution of sodium nitroprusside (SNP) in a range between 0.1% weight/weight (w/w) to 10% w/w; and a coating disposed on the polymer base, wherein the coating includes an antimicrobial agent and the antimicrobial agent is a biguanide.