| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for influencing the miR-92 expression in cells for promotion of angiogenesis, vascularization or vessel repair, or for inhibition or blocking of tumor angiogenesis.SOLUTION: The invention provides a method comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, where the construct includes an expressible miR-92 sequence. In the method, the provided cell may stem from a metazoan, in particular, from a mammal. Furthermore, the invention provides a pharmaceutical composition comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.SELECTED DRAWING: None |
