发明名称 |
MATRIX METALLOPROTEASE INHIBITORS |
摘要 |
2096221 9209556 PCTABS00013 Compounds of formulas (1) or (2) wherein each R1 is independently H or alkyl (1-8C) and R2 is alkyl (1-8C) or wherein the proximal R1 and R2 taken together are -(CH2)p- wherein p = 3-5; R3 is H or alkyl (1-4C); R4 is fused or conjugated unsubstituted or substituted bicycloaryl methylene; n is 0, 1 or 2; m is 0 or 1; and X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine; wherein R6 is H or lower alkyl (1-4C) and R7 is H, lower alkyl (1-4C) or an acyl group, and wherein -CONR3- is optionally in modified isosteric form are useful for treating conditions which are characterized by unwanted matrix metalloprotease activities.
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申请公布号 |
CA2096221(A1) |
申请公布日期 |
1992.05.22 |
申请号 |
CA19912096221 |
申请日期 |
1991.11.21 |
申请人 |
GALARDY, RICHARD E.;GROBELNY, DAMIAN |
发明人 |
GALARDY, RICHARD E.;GROBELNY, DAMIAN |
分类号 |
A61K31/16;A61K31/165;A61K31/195;A61K31/21;A61K31/215;A61K31/22;A61K31/27;A61K31/325;A61K31/40;A61K31/403;A61K31/404;A61K31/405;A61K31/445;A61K31/454;A61K31/47;A61K31/472;A61K31/505;A61K38/55;A61P1/04;A61P9/00;A61P11/16;A61P17/00;A61P29/00;A61P35/00;A61P43/00;C07C259/06;C07C271/60;C07D209/20;C07D215/06;C07D215/12;C07D217/04;C07D217/14;C07D239/26;C07K5/06;C12N9/99;G01N33/53;G01N33/573;(IPC1-7):C07D209/20;A61K38/05;C07D401/06;C07D215/14;C07D217/16;A61K31/395;A61K39/395 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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地址 |
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