Process for the synthesis of nucleoside-5'-alkylphosphonates.

摘要

A nucleoside-5 min -alkylphosphonate is synthesized by reacting a nucleoside, optionally having protected hydroxyl groups at the 2 min - and 3 min -positions, with an alkylphosphonic halide, or reacting a nucleoside in which the hydroxyl groups at the 2 min - and 3 min -positions are protected with an alkylphosphonic acid or alkylphosphonic halide in the presence of a condensation agent.