| 摘要 |
PURPOSE:To obtain the title new substance useful for preventing and treating diseases such as hyperlipemia or arteriosclerosis caused by accumulation of cholesterol because of possession of extremely inhibitory activity against acylcoenzyme A cholesterol acyltransferase. CONSTITUTION:FO-1,513 substance having the following properties. Molecular formula: C45H82O5. Molecular weight: 702. Solubility: soluble in methanol, benzene, etc.: insoluble in water. Distinction of basicity, acidity and neutrality: neutrality. Color and property: colorless oily state. The substance is prepared by culturing a fungus [e.g. Gliocladium sp. FO-1,513 (FERM P-12,220), new fungus] belonging to the genus Gliocladium, capable of producing FO-1,513A substance and collecting the substance from the culture mixture. The culture is preferably carried out under an aerobic condition at pH near neutrality at 24-30 deg.C for 2-3 days. |
