发明名称 SALTS OF HYDRAZONES
摘要 4-18815/A Salts of hydrazones The invention relates to acid addition salts of bases of formula I <IMG> (I), wherein A, R1, R2, R3, R4, R5, X and Z are as defined in the description, with an acid ¢PA! that is a mono- or poly-protic acid selected from carbonic acid, alkanoic acids that are unsubstituted or mono- or poly-substituted, with the exception of formic acid, unsubstit-uted acetic acid, lysine and arginine; alkenoic acids that are unsubstituted or substituted, with the exception of unsubstituted fumaric acid; cycloalkylcarboxylic acids, aryl-carboxylic acids, aryl-lower alkylcarboxylic acids, wherein lower alkyl is unsubstituted or substituted, aryl-lower alkenylcarboxylic acids, heterocyclylcarboxylic acids, alkane-sulfonic acids that are unsubstituted or substituted, with the exception of unsubstituted methanesulfonic acid; aromaticsulfonic acids, alkylsulfuric acids, N-substituted sulfamic acids, organic acids without carboxy, sulfo, sulfate or phospho groups, and also selected from pyrophosphoric acid and hydriodic acid; and tautomers thereof. The acid addition salts are used in the treatment of disorders that respond to inhibition of S-adenosyl-methionine decarboxylase.
申请公布号 CA2080545(A1) 申请公布日期 1993.04.17
申请号 CA19922080545 申请日期 1992.10.14
申请人 CIBA-GEIGY AG 发明人 STANEK, JAROSLAV;FREI, JOERG;CARAVATTI, GIORGIO
分类号 A61K31/165;A61K31/15;A61K31/155;A61K31/17;A61K31/18;A61K31/185;A61K31/19;A61P31/00;A61P33/02;A61P33/06;A61P35/00;A61P35/04;C07C51/41;C07C251/80;C07C281/18;C07C303/32;C07C309/05;C07C309/29;C07C309/35;C07C327/48;C07C337/08;(IPC1-7):C07C281/18;A61K31/175;C07C281/12 主分类号 A61K31/165
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