主权项 |
1. An isolated monoclonal antibody which specifically binds human TIMP-2, wherein the monoclonal antibody binds with an affinity of at least 108 M−1 to a polypeptide, the sequence of which consists of a sequence selected from the group consisting of:(SEQ ID NO: 1)QAFCNADVVIRAKAVSEKEVD,(SEQ ID NO: 2)IYGNPIKRIQYEIKQI,(SEQ ID NO: 3)YEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDG,(SEQ ID NO: 4)YEIKQIKMFKGPEKDIEFIYTAPSSAV,(SEQ ID NO: 5)EFIYTAPSSAVCGVS,(SEQ ID NO: 6)TAPSSAVCGVSLDVGGKKEYLIAGKA,(SEQ ID NO: 7)SLDVGGKKEYLIAGKAEGDGK,(SEQ ID NO: 8)SSPDECLWMDWVTEKNINGHQ,and(SEQ ID NO: 9)CAWYRGAAPPKQEFLDIEDP. |