Aminoalkyl benzothiazolinones process for their preparation and the pharmaceutical compositions which contain them

摘要

Aminoalkyl benzothiazolinones of formula (I), their optical isomers, and their acid and base addn. salts, are new. R1 = H or opt. substd. alkyl; R2 = -(CH2)3-N(R3)R4 (gp.R21), or a gp. of formula (R22); R3, R4 = H, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl or -(CH2)m-aryl (opt. substd. on aryl by one or more halo, hydroxy, alkyl (opt. substd. by one or more halo) or lower alkoxy); m = 0-4; or NR3R4 = a 5-9 atom heterocyclic gp., opt. contg. further heteroatoms (O or S) (opt. substd. by one or more alkyl), or form a 4-(methoxyphenyl)-piperazin-1-yl gp.; n = 2-4; R5, R6 = H or halo; alkyl and alkoxy are 1-6C; alkenyl and alkynyl are 2-6C; aryl = phenyl or naphthyl; cycloalkyl is 3-8C.