发明名称 |
Process for preparing N-acylated 4-hydroxypenylamine derivatives with analgesic properties |
摘要 |
The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group of formula I: <IMAGE> I in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.
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申请公布号 |
US5621110(A) |
申请公布日期 |
1997.04.15 |
申请号 |
US19950529549 |
申请日期 |
1995.09.18 |
申请人 |
LSU MEDICAL CENTER FOUNDATION |
发明人 |
BAZAN, NICOLAS G.;GOMEZ, JULIO ALVAREZ-BUILLA |
分类号 |
A61K31/00;A61P29/00;C07D275/06;(IPC1-7):C07D275/06 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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