| 摘要 |
A process for the preparation of compounds of formula (II) wherein R<1> is lower alkoxy, lower alkylamino, di-(loweralkyl)amino, or the monovalent radical A-NR<3>, wherein A is lower alkyl or A is R<4>R<5>NC(O)CH2 wherein, for example, R<4> is hydrogen or alkyl and R<5> is hydrogen, alkyl or a substituted alkyl, or R<5> is R<6>R<7>N-Alk wherein R<6> and R<7> each is hydrogen or lower alkyl and Alk is a divalent alkyl radical; R<3> is, for example, benzyl, alkyl or a substituted alkyl; and R<2> is, inter alia, alkyl, cycloalkyl, 1H-imidazol-4-yl, 4-thiazolyl or 2-amino-4-thiazolyl; through the kinetic resolution of a compound of formula (III) wherein R<1> is as defined herein, R<2> is as defined herein, and B is lower alkyl. These compounds are useful intermediates in the synthesis of renin inhibiting compounds.
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