OXIDATIVE METHOD FOR ATTACHMENT OF GLYCOPROTEINS TO SURFACESOF MEDICAL DEVICES

摘要

A method for making a medical device having a glycoprotein immobilized on a substrate surface is provided. The method includes oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functional material; combining thealdehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and reacting the imine moiety with areducing agent to form a secondary amine.