| 发明名称 |
Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors |
| 摘要 |
The invention relates to novel cyclopeptides of the formula Icyclo-(Arg-B-Asp-D-E)Iin which B, D, and E have the meanings defined herein, and their salts. These compounds act as integrin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
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| 申请公布号 |
US5849692(A) |
申请公布日期 |
1998.12.15 |
| 申请号 |
US19960616770 |
申请日期 |
1996.03.15 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG |
发明人 |
JONCZYK, ALFRED;HOLZEMANN, GUENTER;FELDING-HABERMANN, BRUNHILDE;RIPPMANN, FRIEDRICH;DIEFENBACH, BEATE;KESSLER, HORST;HAUBNER, ROLAND;WERMUTH, JOCHEN |
| 分类号 |
A61K38/00;A61K38/08;A61K38/12;A61P9/00;A61P19/00;A61P35/00;C07K1/113;C07K1/22;C07K7/52;C07K7/64;C07K14/75;C07K14/78;C07K17/08;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
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