摘要 |
The present invention relates to certain tetrahydroimidazoÄ2,1-aÜisoquinoline derivatives according to formula I <CHEM> wherein X is a group (A) or (B) <CHEM> R<1>, R<2> and R<3>, which may be the same or different, each represent one or more substituents selected from hydrogen, C1-6alkyl, C3-6cycloalkyl C1-6alkoxy, C1-6alkylthio, C4-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl and halogen; R<4>, R<5>, R<6> and R<7>, which may be the same or different, are each selected from hydrogen, C1-6alkoxyC1-6alkyl, C4-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl and C1-6alkyl; n is 1 or 2; or a pharmaceutically acceptable salt or solvate thereof, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of depression. |