Recombinant production of murine interferon- gamma (IFN- gamma ) inducing factor (IGIF, IL-18)

摘要

DNA encoding a murine protein capable of inducing the production of interferon- gamma by immunocompetent cells is described. The native protein from mouse liver has a molecular weight of 19+/-5 kDa, a pI of 4.8+/-1.0, and the amino acid sequence shown in SEQ ID NO: 2. Methods for producing the protein in recombinant expression systems including E. coli are provided.