Administration of serine protease inhibitors to the stomach

摘要

The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.

主权项

1. An aqueous pharmaceutical formulation comprising a therapeutically effective amount of 0.16 wt % to 1.80 wt % of tranexamic acid, polyethylene glycol-3350, and electrolytes; wherein the formulation has a volume of 500 ml to 1000 ml.