发明名称 |
PEPTIDE AND POLYPEPTIDE INHIBITORS OF COMPLEMENT C1S |
摘要 |
The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation. |
申请公布号 |
WO0198365(A2) |
申请公布日期 |
2001.12.27 |
申请号 |
WO2001US19405 |
申请日期 |
2001.06.18 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
WEST, ROBERT, R.;SHEPPARD, PAUL, O.;FOX, BRIAN, A. |
分类号 |
A61K38/00;A61P29/00;A61P31/00;C07K14/435;C07K14/815 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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