摘要 |
A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a C 6-10 aryl group; R 1 and R 2 independently represent H, OH, X, CN, NO 2 a C 1-4 haloalkyl group, a C 1-6 alkyl group, or the like <R 1 and R 2 together form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group>; R 3 represents H, a C 1-5 alkyl group, a C 6-10 aryl group, a C 1-5 alkyl group, or a C 1-4 haloalkyl group; and R 4 represents H, X, a C 1-3 alkyl group, a C 1-4 haloalkyl group, OH, CN, NO 2 or the like.) |
申请人 |
Chugai Seiyaku Kabushiki Kaisha;F.Hoffmann-La Roche AG |
发明人 |
TAKA, Naoki;OHMORI, Masayuki;TAKAMI, Kyoko;MATSUSHITA, Masayuki;HAYASE, Tadakatsu;HYODO, Ikumi;KOCHI, Masami;NISHII, Hiroki;EBIIKE, Hirosato;NAKANISHI, Yoshito;MIO, Toshiyuki;WANG, Lisha;ZHAO, Weili |