9-HYDROXYPHEOPHORBIDE-A DERIVATIVE AS PHOTOSENSITIZER IN NOVEL PHOTODYNAMIC THERAPY

摘要

PURPOSE: Provided is 9-hydroxypheophorbide-a derivative as photosensitizer in novel photodynamic therapy. The 9-hydroxypheophorbide-a derivative has more hydrophilicity than 10-hydroxypheophytin a and increased photodynamic therapy effects. CONSTITUTION: The 9-hydroxypheophorbide-a derivative of the formula(I) is manufactured by reducing carbonyl group at C9 of pheophytin a which is removed from metal ion of chlorophyll a then hydrolyzing ester group. In the formula, R1 and R2 are individually represent hydrogen, C1-6 linear or branched alkyl or C3-8 aryl, wherein R1 is preferably methyl and R2 is preferably hydrogen.