Pyrroloquinoline alkaloids as antimalarial agents and process for the preparation thereof

摘要

The patent provides novel compounds with potential anti-malarial activity and process of synthesis thereof. Further, the process for the synthesis of known antimalarial natural products marinoquinazolinone A-F, aplidiopsamine A and their potential antimalarial analogs is disclosed.

主权项

1. A compound of formula I or a pharmaceutically acceptable salt thereof, wherein R, R1, and R2 are selected from the group consisting of H, halide, alkyl, aryl, hetero alkyl, and hetero aryl, X is H, halide, OTf, or OTs, R3 is a compound of formula III, and R4 is selected from the group consisting of H, halide, alkyl, aryl, hetero alkyl, and hetero aryl.