PREDICTING RAPID DECLINE IN RENAL FUNCTION IN DIABETES

摘要

Methods of predicting rapid decline in renal function in diabetes employing panels of biomarkers. The methods are useful for predicting risk of decline of renal function in individual subject and also for selecting subjects for clinical trials.

主权项

1. A method of determining renal function decline risk in a subject, comprising (a) analysing one or more samples obtained from the subject for the level of each of a plurality of biomarkers, (b) comparing the measured levels of each of the plurality of biomarkers with a respective plurality of control levels, and (c) determining renal function decline risk in the subject from the comparison, wherein the said plurality of biomarkers comprise at least 7 of the group consisting of: (i) adrenomedullin; (ii) alpha-1 antitrypsin; (iii) beta-2-microglobulin or cystatin-C; (iv) c16-acylcarnitine; (v) creatine; (vi) creatinine; (vii) fatty acid-binding protein, heart; (viii) fibroblast growth factor 21; (ix) hydroxyproline; (x) kidney injury molecule-1; (xi) N-terminal prohormone of brain natriuretic peptide; (xii) the ratio of symmetric dimethylarginine to asymmetric dimethylarginine; (xiii) symmetric dimethylarginine; and (xiv) uracil.