| 主权项 |
1. A method for determining the efficacy of a small molecule for inhibiting one or more of cyclin-dependent kinase 8 (CDK8) and cyclin-dependent kinase 19 (CDK19), the method comprising obtaining, from a subject that has been administered the small molecule and has not been administered interferon-γ, a tissue sample or a sample derived from a tissue sample, other than natural killer cells, assaying the sample for signal transducer and activator of transcription protein 1 (STAT1) that is phosphorylated at serine 727 (pSTAT1), quantitating the amount of pSTAT1 in the sample, comparing the amount of pSTAT1 in the sample with an amount of pSTAT1 in a standard, and determining that the small molecule has efficacy for inhibiting CDK8/19 if the amount of pSTAT1 in the sample is statistically significantly lower than the amount of pSTAT1 in the standard. |
