Methods and Compositions for the Treatment of Vaginal Diseases Employing Peroxide-Producing Enzymes and Peroxidases

摘要

A therapeutic composition for vaginal administration based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generated by the action of an oxidase enzyme on a suitable substrate. Therapeutic compositions according to the present invention are useful for the treatment of vaginal diseases and conditions, including bacterial and fungal infections.

主权项

1. Use of a composition formulated for vaginal administration to treat a vaginal condition, the composition comprising:
(a) a peroxidase enzyme selected from the group consisting of lactoperoxidase, horseradish peroxidase, myeloperoxidase, eosinophil peroxidase and glutathione peroxidase; (b) a salt that is an alkali metal salt of an anion selected from the group consisting of thiocyanate, iodate and chlorate; (c) at least one of an ingredient selected from the group consisting of lysozyme, lactoferrin and a steroid; and (d) an amount less than 15% of PEG 20,wherein the composition is a lubricant, further wherein the lubricant has a pH suitable for maintaining a stable Lactobacillus population within a vagina.