CHOLESTEROL EFFLUX CAPACITY ASSESSMENT

摘要

A method is provided for transforming one or more biomarkers into a cholesterol efflux capacity (CEC) value. Methods relate to determining SR-BI-mediated and ABCA1-mediated CEC. CEC may be used for compound screening and to determine risk of cardiovascular disease and to recommend or administer treatment regimens.

主权项

1. A method for determining an ABCA1-mediated cholesterol efflux capacity (CEC) of an individual comprising:
obtaining a sample from an individual; measuring a triglyceride level in the sample; receiving the triglyceride level at a computing device comprising a tangible, non-transient memory coupled to a processor; transforming the triglyceride level into an ABCA1-mediated CEC value for the individual through the application, by the processor, of a predetermined rule, wherein the predetermined rule is stored in the tangible, non-transient memory; and creating a written report comprising the ABCA1-mediated CEC value for the individual.