| 摘要 |
<p>1470355 Anti-acne composition MERCK & CO INC 23 June 1975 [1 July 1974] 26573/ 75 Heading A5B An anti-acne composition for topical administration comprises from 0.01 to 0.2% by weight of at least one of 1, 1'-hexamethylenebis-5-(hexyl)biguanide, 1, I'-hexamethylenebis- 5-(heptyl)biguanide, 1, 1'-hexamethylenebis-5- (n-octyl)biguanide, 1, 1'-hexamethylenebis-5-(2- ethylhexyl)biguanide and 1, 1'-hexamethylenebis-5-(nonyl)biguanide and their pharmaceutically acceptable acid-addition salts as antiacne agent; at least one of lauryl lactate, methyl pyrrolidone, methyl salicylate and Vitamin A acid as skin-penetrating agent, in which the lauryl lactate constitutes from 10 to 20% by weight of the formulation, the methyl pyrrolidone constitutes from 36 to 41% by weight of the formulation, the methyl salicylate constitutes from 5 to 9% by weight of the formulation and the Vitamin A acid constitutes from 0.05 to 0.1% by weight of the formulation; and a pharmaceutically acceptable solvent suitable for topical application. The composition may further comprise 0.01-0.15% by weight of bactylated hydroxy toluene, butylated hydroxy anisole and/or ascorbic acid as anti-excipient and may be made up as a lotion, freshener, cream, ointment, jelly, salve or emulsion.</p> |
