| 主权项 |
1. A compound of formula (I) wherein A is —CH— or nitrogen; R1 is halophenyl, halophenylalkyl, haloalkoxy, halogen, alkoxyalkoxy, oxopyrrolidinyl or cycloalkylalkoxy; R2 is hydrogen, halophenylamino, cycloalkyl or haloazetidinyl; one of R3 and R4 is hydrogen and the other one is —(CR5R6)m—(CH2)n—R7; or R3 and R4 together with the nitrogen atom to which they are attached form aminocarbonylthiomorpholinyl; R5 and R6 are independently selected from hydrogen and alkyl; R7 is 5-cycloalkyl-1,3,4-oxadiazolyl, 3-cycloalkyl-1,2,4-oxadiazolyl, 5-phenyl-1,3,4-oxadiazolyl, 3-phenyl-1,2,4-oxadiyzolyl, 5-alkyl-1,3,4-oxadiazolyl, 3-alkoxyalkoxyalkyl-1,2-oxazolyl, 1-hydroxyalkylpyrazolyl, 3-hydroxy-1-adamantyl, alkoxycarbonylmorpholinyl, 3-oxanyloxyalkyl-1,2-oxazol-5-yl, 3-azidoalkyl-1,2-oxazol-5-yl or 5-(4-fluorophenyl)-1,3,4-oxadiazolyl; m is 0 or 1; n is 0 or 1; or a pharmaceutically acceptable salt or ester thereof; provided that 6-chloro-N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-2-pyridinecarboxamide is excluded. |
