| 摘要 |
<p>A penicillin derivative of the formula I:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="35" wi="79" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which R<Sup>1</Sup> is any one of the C-3 substituents from antibacterially-active penicillins known in the art; ⊕
<UnorderedLists id="ula01" listStyle="none"><ListItem>X is a nitrogen atom or a radical of the formula N-R<Sup>3</Sup>; R<Sup>2</Sup> and R<Sup>3</Sup>, which may be the same or different, are hydrogen atoms or 1-6C alkyl, 1-6C alkanoyl, hydroxy, 1-6C alkoxy, amino, 1-6C alkanoylamino, 1-6C alkylamino, 1-6C aminoalkyl, 1-6C hydroxyalkyl, 2-6C carboxyalkyl, 2-6C alkenyl, 3-6C alkoxyalkyl, 3-8C alkoxycarbonylalkyl, furylmethyl, phenyl or 7-11 C phenylalkyl radicals, in the latter two of which the phenyl ring is optionally substituted by a halogen atom or by a methyl, methoxy, nitro, hydroxy, amino, carboxy or methoxycarbonyl radical;</ListItem><ListItem>A<is a radical of the formula II or III:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="34" wi="56" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which R<Sup>4</Sup>, R<Sup>5</Sup>, <Sub>R</Sub><Sup>6</Sup>, R<Sup>7</Sup>, R<Sup>8</Sup> and R<Sup>9</Sup> are as described in the specification; and the pharmaceutically-acceptable acid- or base-addition salts thereof. Pharmaceutical compositions and manufacturing processes are also described.</ListItem></UnorderedLists></p> |
