| 摘要 |
PURPOSE:The reaction between an alcohol derivative, an amide and carbon monoxide is effected in the presence of cobalt and a platinum group metal catalyst, to produce the titled compound from inexpensive and readily available raw materials through the one-stage process in high yield. CONSTITUTION:The reaction between an alcohol derivative of formulaI (R<1>, R<2>, R<3> are H, alkyl, aryl; n is 1, 2), an amide of R<4>CONHR<5> (R<4> means the same as R<1>-R<3>; R<5> is H, alkyl) and carbon monoxide is conducted in a solvent such as tetrahydrofuran or benzene in the presence of a catalyst consisting of cobalt compound such as Co2(CO)8 and a compound of a platinum group metal such as RhCl3.3H2O, preferably under 1-100 atmospheric pressure of hydrogen at 100-200 deg.C to give the objective compound of formula II (m is 0, 1). |
