MODIFIED RELEASE FORMULATIONS OF MEMANTINE ORAL DOSAGE FORMS

摘要

The present invention provides pharmaceutical compositions given once daily containing at least one therapeutically active ingredient selected from the group consisting of memantine and a pharmaceutically acceptable salt of memantine, and a pharmaceutically acceptable polymeric matrix carrier. The dosage forms of the invention sustain the release of the therapeutically active agent from about 4 to about 24 hours when said dosage form is exposed to aqueous solutions. following entry of said form into a use environment, wherein said dosage form has a dissolution rate of more than about 80% after passage of about 6 hours to about 12 hours following said entry into said use environment.

主权项

1. A modified release solid oral dosage form comprising:
(a) at least one therapeutically active ingredient selected from the group consisting of memantine and a pharmaceutically acceptable salt of memantine, and (b) a pharmaceutically acceptable polymeric carrier substantially contributing to the modification of the release of said active ingredient,said dosage form sustaining release of said therapeutically active agent from about 4 hours to about 24 hours following entry of said form into a use environment, wherein said dosage form has a dissolution rate of more than about 80% after passage of about 6 hours to about 12 hours following said entry into said use environment.