| 摘要 |
NEW MATERIAL:A compound of formula I (R is 1-4C alkyl). EXAMPLE:Ethyl 2-(2-amino-5-thiazolyl)-2-hydroxyacetate. USE:A starting substance of intermediates of medicines: it is readily soluble in common solvents such as methanol, acetone or ethyl acetate to enable homogeneous liquid-phase reactions which have been conventionally impossible. Further, it is used in quite same uses as ATHA. PREPARATION:For example, a mixture of 2-(2-amino-5-thiazolyl)-2-hydroxyacetic acid (abbreviated to ATHA) of formula II with an alcohol of R-OH is combined with thionyl chloride and the reaction is effected at -20-50 deg.C to give a compound of formula I .
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