| 摘要 |
An immobilized structure comprising multiple monolayers of effective sequential polymeric linkages can be built, monolayer by monolayer, from the surface of a solid phase, by an alternating reaction sequence conducted with multifunctional reagents. The solid phase has an attached reactive moiety and is reacted with a first multifunctional reagent having one functional group reactive with the moiety of the solid phase and one functional group reactive with the second multifunctional reagent, the resulting intermediate adduct is reacted with the second multifunctional reagent to produce a first monolayer. This sequence of alternating reactions with first and second multifunctional reagents is repeated as often as desired to produce an immobilized structure of multiple monolayers. The process makes it possible to form numerous immobilized multiple monolayer structures wherein the length of each structure extending from a substrate is substantially the same. Structures comprising multiple monolayers of polymeric linkages are useful for immobilizing macromolecules or biomolecules to produce chemical or biochemical sensors. Other uses extend to molecular electronic applications, such as the production of molecular conductive wires and molecular circuitry. |
