发明名称 |
IL-37 VARIANTS |
摘要 |
This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric anti-inflammatory polypeptide comprising an amino acid sequence of an IL-37 monomer, the amino acid sequence having a mutation or modification for preventing the anti-inflammatory peptide from forming a homodimer. |
申请公布号 |
WO2016201503(A1) |
申请公布日期 |
2016.12.22 |
申请号 |
WO2016AU50495 |
申请日期 |
2016.06.15 |
申请人 |
MONASH UNIVERSITY;PRINCE HENRY'S INSTITUTE OF MEDICAL RESEARCH |
发明人 |
NOLD, Marcel;NOLD, Claudia;ELLISDON, Andrew;WHISSTOCK, James |
分类号 |
C07K14/54;A61K38/20;A61P29/00;C12N15/24;C12N15/63;C12N15/85 |
主分类号 |
C07K14/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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