| 摘要 |
PURPOSE:To industrially and advantageously obtain the titled compound useful as an agricultural chemical, etc., in high yield, by reacting 2-hydroxy-1,4- naphthoqinone with an aldehyde in the presence of an acid having an acidity stronger than that of lower fatty acids and weaker than that of hydrochloric acid in an inert organic solvent. CONSTITUTION:2-Hydroxy-1,4-naphthoquinone is reacted with a >=2C aldehyde having at least one H at the alpha-position in an inert organic solvent (preferably lower fatty acid) in the presence of an acid having about 0-4.8pKa, preferably about 0-3pKa within the range of stronger than that of the lower fatty acid and weaker than that of hydrochloric acid to industrially and advantageously afford the titled compound useful as a raw material for insecticides, medicines, veterinary drugs and agricultural chemicals in high purity and yield at a low cost with facilitated separation of the product without requiring special corrosion-resistant materials due to no use of extremely highly corrosive hydrochloric acid though a smaller amount of the aldehyde used than a conventional one is sufficient, etc. |
