Environmentally responsive hydrogels for delivery

摘要

A nanosensor-containing polymer composition for the monitoring of physiological parameters and a method for making the composition are disclosed. The composition includes a fluid nanosensor-containing polymer that becomes rigid in the presence of physiological conditions. In the fluid form, the composition can be suitable for injection on to or into the skin. In the rigid form, the nanosensor is substantially immobilized in the polymer. The method includes forming a mixture comprising a nanosensor and polymer precursor(s), subjecting the mixture to conditions suitable for forming the fluid form of the composition; and subjecting the fluid form to physiological conditions to provide a rigid nanosensor-containing composition.

主权项

1. A composition, comprising:
a nanosensor comprising a nanoparticle having a detectable label, wherein the nanosensor is configured to interact with a specific analyte in an intradermal environment; and a polymer comprising first monomer-derived units and second monomer-derived units, wherein
the first monomer-derived units have the structure of formula (Ia): whereinX is —O— or —S—;y is 0-10;R1 is hydrogen or methyl; andR2 is hydrogen, —C1-C12alkyl, —C1-C12alkyl-OH, —SiR′3, —C(O)—C1-C12alkyl, —C1-C12alkyl-C(O)OR′, wherein R′ is —C1-C12alkyl,the second monomer-derived units have the structure of formula (II): wherein
R3 is a hydrophobic group; andR4 is hydrogen or methyl, wherein the polymer is configured to change from a fluid form to a rigid form in response to a temperature increase; wherein the nanosensor is disposed in the polymer.