PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES

摘要

Compounds of the formula I wherein R1 is halogen, C1-4-alkyl, halo-(C1-4-alkyl) or C2-4-alkanoyl, R2 is hydrogen, hydroxy, C1-4alkoxy, C1-4-alkylthio or phenyl-(C1-4-alkoxy) or , when X is O, also acyloxy, R3 is hydrogen or C1-4-alkyl, R4 is a carbocyclic group or a heterocyclic group, R5 is hydrogen or fluorine, m stands for zero, 1 or 2, X is O or NH and Y is a direct bond, -CH=CH-, -C 3BOND C- or a group of the formula of -(Z)n-A-(a) in which A is a C1-8alkylene group which is optionally substituted by one or two phenyl groups, Z is O, S, SO or SO2 and n stands for zero or 1, with the proviso that R1 is different from iodine, when R2 is hydroxy or benzoyloxy, R3 is hydrogen, R4 is unsubstituted phenyl, R5 is hydrogen, m stands for zero, X is O, and Y is a direct bond, and tautomers thereof, which possess antiviral activity and can therefore be used in the form of medicaments for the control and prevention of viral infections are described. The compounds of formula I can be prepared according to known methods.