Inhibitor of protein kinase c

摘要

The present invention provides peptides of general formula (I): X-Ala-Arg-Arg-J wherein X is H or one or more amino acids and J is OH or one or more amino acids, and pharmaceutically acceptable derivatives thereof, which peptides contain 3 to 15 amino acid residues. The invention also provides antisense oligonucleotides and derivatives thereof corresponding to the DNA coding for zeta -PKC, especially the oligonucleotide having the sequence GGTCCTGCTGGGCAT (SEQ ID NO 14). The novel peptides and oligonucleotides are of use in medicine for the treatment of conditions whose underlying aetiology is associated with zeta -PKC activity, for example tumours, hyperproliferative disorders and viral infections. Processes for preparing the novel compounds, pharmaceutical compositions containing them and their use in medicine are described.