COMBINATION ARTEMISININ AND CHEMILUMINESCENT PHOTODYNAMIC THERAPY AND USES THEREFOR

摘要

Photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid (ALA), luminol and artemisinin (ART). ART and ALA administered in combination with luminol can kill malaria parasites without host toxicity. In some aspects, the methods further include administration of a luminol enhancer such as 4-iodophenol. The disclosed methods can also be used to remove potential malaria pathogens from the blood supply.

主权项

1. A method of killing intraerythrocytic parasites, the method comprising contacting the parasites with therapeutically effective amounts of: 5-aminolevulinic acid or a derivative thereof; luminol or a derivative thereof; and artemisinin or a derivative thereof.